Types of Lung Cancer Tumors
Tuesday, September 18, 2018
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lung cancer tumors via epainassist.com |
Lung cancer is the number one cause of cancer death in the United States as well as in the
world and the particular form of lung cancer that's particularly deadly is called K rass mediated
lung adenocarcinoma which is the form of cancer that was a subject of this study in particular
most patients who are treated for k-rod mediated lung adenocarcinoma will respond to
therapy but eventually often succumb to relapse and with resistant disease in our previous
studies we had identified a compound which is a potent inhibitor of pkc iota so in the second
part of our study we asked whether this compound was effective in inhibiting the growth of K
wrassling I'd no carcinoma and we found that in fact it was but we went further because many
targeted therapeutics such as a peak a co2 inhibitor for instant can work better if they're used
in combination with other drugs that target other molecular abnormalities in particular cancer
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so in this case we actually showed that combining two inhibitors that inhibit different parts of
the pathway that we discovered were synergistic in their antitumor activity that is they work
better together than either of them alone using these two drugs we found that we could halt
the growth of K rass lung adenocarcinoma cells both in vitro in the laboratory as well as in
preclinical models of the disease the clinical implications of this study could be far-reaching k
rass the gene the oncogene that drives this particular type of cancer has been very difficult to
therapeutically target and in fact tumors that Harbor k rass mutations are very difficult to
treat so one implication is that we now have a therapeutic approach that can specifically
target k rass mediated tumors now k wrasse is not only an oncogene major oncogene in this
form of lung cancer but also other types of cancer such as pancreatic cancer and colon cancer
so there are other types of tumors for which this therapeutic approach may also work.
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